| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860851 | Toxicology Letters | 2011 | 7 Pages |
Abstract
⺠Deuteration of PUFA protects from nigrostriatal damage in a preclinical PD model. ⺠Substitution at bis-allylic sites in LA and ALA prone to autoxidation is protective. ⺠PUFA isotopic reinforcement may be a strategy to diminish nigrostriatal degeneration.
Keywords
RCPDOPACMPTPMAOHNEALAMDA4-hydroxynonenal1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine3,4-dihydroxyphenylacetic acid4-HydroxyhexenalROSOxidative injuryLinoleic acidLinolenic acidPolyunsaturated fatty acidPUFAParkinson's diseasetyrosine hydroxylaseHhedeuteriumDopaminemalondialdehydeMouse modelNigrostriatal pathwaymonoamine oxidasehomovanillic acidHVAReactive oxygen species
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Mikhail S. Shchepinov, Vivian P. Chou, Erik Pollock, J. William Langston, Charles R. Cantor, Robert J. Molinari, Amy B. Manning-BoÄ,