| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860854 | Toxicology Letters | 2011 | 7 Pages |
Abstract
⺠We studied three known polymorphisms (rs11568816, rs17028487, rs13832) of the FDH gene (gene of the GSH-dependent formaldehyde dehydrogenase). ⺠The polymorphic sequence was only found for rs13832. ⺠The genetic polymorphism did neither lead to a significant difference in the transcript level nor to altered protection of the cells towards formaldehyde-induced DNA damage. ⺠This study did not identify biologically relevant polymorphisms in transcribed regions of the FDH gene which may lead to inter-individual differences in the metabolic inactivation of formaldehyde.
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Authors
Walter Just, Jasmin Zeller, Clarissa Riegert, Günter Speit,