| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860858 | Toxicology Letters | 2011 | 6 Pages |
Abstract
⺠Silver nanoparticles (AgNPs) induce reactive oxygen species (ROS) generation. ⺠8-Oxoguanine (8-oxoG) is sensitive marker of ROS-induced DNA damage. ⺠8-Oxoguanine DNA glycosylase 1 (OGG1) is a repair enzyme that excises 8-oxoG. ⺠AgNPs accumulate 8-oxoG in DNA via down-regulation of OGG1 gene expression. ⺠The inability of OGG1 by AgNPs occurs via inactivation of Nrf2, ERK and AKT.
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Authors
Mei Jing Piao, Ki Cheon Kim, Jeong-Yun Choi, Jinhee Choi, Jin Won Hyun,