Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5861418 | Toxicology in Vitro | 2015 | 6 Pages |
Abstract
The HSC activation is independent of FFA accumulation but requires cell-to-cell interaction with hepatocyte. On the contrary, the gene regulation of ECM components seems to occur through paracrine mediators.
Keywords
GFAPNAFLDTIMPsMMP2FFAECMSCCMmpsα-SMAFBSPBSHSCDMSOalpha smooth muscle actinFatty acidsFree fatty acidsnon-alcoholic fatty liver diseasedimethyl sulphoxidefetal bovine serumHepatic stellate cellsExtracellular matrixMatrix metalloproteinasesPhosphate-buffered salineGlial fibrillary acidic proteinHeat shock protein 47Gelatinase ACol1
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Authors
Varenka J. Barbero-Becerra, Pablo J. Giraudi, Norberto C. Chávez-Tapia, Misael Uribe, Claudio Tiribelli, Natalia Rosso,