Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5861930 | Toxicology in Vitro | 2014 | 8 Pages |
Abstract
Decreasing cellular glutathione and the activity of some antioxidative enzymes by glucocorticoid pretreatment had no effect on toxicity of zinc or tBHP in L2 cells in suspensions, while toxicity in monolayers was increased. Glucocorticoid pretreatment seems to increase toxicity of HP in A549 monolayers according to the lowered protein content, while toxicity might be changed by a different way when cells are incubated as cell suspensions. No explanation as a cell culture artificial effect was observed, therefore we assume the increased toxicity after glucocorticoid pretreatment occurs in vivo as well.
Keywords
BSOHBSSFCSDTNBCysGSSGGSHNADPHCATtBHPDEXSDSPBSSodium laurylsulfatel-Cysteinel-methionineHydrogen peroxideEDTAbuthionine sulfoximineminimum essential mediumDexamethasonefetal calf serumtertiary butylhydroperoxideMEMPhosphate-buffered salineHanks’ balanced salt solutionMETMIIHydrocortisoneCatalasezinc chlorideglutathione, oxidized formglutathione, reduced form
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Authors
Finni Wittek, Salar Torabi, Manuela Kolb, Udo Ingbert Walther,