A MINLP approach for layout designs based on the domino hazard index

•A MINLP model is proposed to optimize facility layouts based on the domino hazard index.•Flame impingement, radiation and fireballs are included to evaluate the domino hazard index value.•The costs for implementing blast, fire insulation and fire resistance walls are also included in the model.•Results for case study clearly show improvements by producing inherent safety in optimal layouts.•Previous work is reformulated to prevent human errors and to ensure optimal solutions.

The Domino Hazard Index used in this work was previously introduced by Tugnoli et al., 2008a and Tugnoli et al., 2008b to assess domino effect hazards caused by a unit in a given layout. This index has been used to compare several layouts in order to select the one with lower risk. A set of piecewise differentiable equations have been developed to describe all graphical descriptions given in the original proposal. Then, this work introduces a complete formulation aimed to achieve optimal facility layouts taking into account the main variables affecting this index. The result of this formulation is a mixed-integer non-linear program (MINLP), which can be solved using a GAMS code. The result can provide substantial support for decision-makers during the design stage.