Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5861955 | Toxicology in Vitro | 2013 | 10 Pages |
Abstract
⺠LC-MS/MS has been used for the detection of reactive species of BPA analogs in HLM and recombinant human P450 isozymes. ⺠BPF, BPAF, BPZ and DMBPA have been evaluated for the formation of reactive species. ⺠Hydroxylation and ipso-substitution derived metabolites of bisphenols were detected. ⺠Arene epoxide, quinone and carbocation intermediates were proposed.
Keywords
BPABPAFESIMRMBPFMBPP450GSHPCPPISHCALC–MS/MSPrecursor ion scanBisphenolsBisphenolBisphenol AFBisphenol FBisphenol ACytochrome P450PhencyclidineReactive metabolitesHuman Liver Microsomesmultiple reaction monitoringreduced glutathioneLiquid chromatography with tandem mass spectrometryEstrogen receptorelectrospray ionization
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Authors
Jan Schmidt, Petra Kotnik, Jurij Trontelj, Željko Knez, Lucija Peterlin MaÅ¡iÄ,