| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5861955 | Toxicology in Vitro | 2013 | 10 Pages |
Abstract
⺠LC-MS/MS has been used for the detection of reactive species of BPA analogs in HLM and recombinant human P450 isozymes. ⺠BPF, BPAF, BPZ and DMBPA have been evaluated for the formation of reactive species. ⺠Hydroxylation and ipso-substitution derived metabolites of bisphenols were detected. ⺠Arene epoxide, quinone and carbocation intermediates were proposed.
Keywords
BPABPAFESIMRMBPFMBPP450GSHPCPPISHCALC–MS/MSPrecursor ion scanBisphenolsBisphenolBisphenol AFBisphenol FBisphenol ACytochrome P450PhencyclidineReactive metabolitesHuman Liver Microsomesmultiple reaction monitoringreduced glutathioneLiquid chromatography with tandem mass spectrometryEstrogen receptorelectrospray ionization
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Jan Schmidt, Petra Kotnik, Jurij Trontelj, Željko Knez, Lucija Peterlin MaÅ¡iÄ,