| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5861959 | Toxicology in Vitro | 2013 | 6 Pages |
Abstract
⺠Cosmetic active ingredients often are mixtures from natural sources. ⺠In vitro tests should be tested for their capacity to assess mixtures. ⺠Botanical mixtures were spiked with different doses of three sensitizers. ⺠The ability of the KeratinoSens⢠assay to detect the spiked constituents was tested. ⺠Analysis allowed determining the minimal level of sensitizers being detectable.
Keywords
IC50Nrf2SOPKeratinoSens™LLNAECVAMMixtureskeap1DMSOLocal lymph node assayregistration, evaluation, authorization and restriction of chemicalsSkin sensitizationDimethylsulfoxideREACHstandard operating procedureNuclear factor-erythroid 2-related factor 2Plant extractsantioxidant response elementAREKelch-like ECH-associated protein 1Reporter gene
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Eric Andres, Vanessa M. Sá-Rocha, Carla Barrichello, Tina Haupt, Graham Ellis, Andreas Natsch,