| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5861966 | Toxicology in Vitro | 2013 | 8 Pages |
Abstract
⺠Tobacco smoke particulate matter is genotoxic in the Ames test, mouse lymphoma assay and micronucleus test. ⺠These in vitro methods can quantitatively resolve the genotoxicity of particulate matter from different cigarettes. ⺠To support the quantitative comparison of particulate matter genotoxicity, statistical methods are recommended. ⺠Replication levels of 4-10 resolved 10-30% differences in particulate matter genotoxicity.
Keywords
ANCOVAMnBnPost-mitochondrial supernatantOECDMLARPMIRTPMCMCDMSOIn vitro micronucleus testISOanalysis of covarianceStatistical analysisstandard error of the meanIn vitrodimethyl sulphoxideparticulate matterMarkov chain Monte CarloOrganisation for Economic Cooperation and DevelopmentGenotoxicityTobacco smokeMutation frequencySEMCooperation Centre for Scientific Research Relative to TobaccoICHRoswell Park Memorial Institute mediumInternational Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human UseCORESTA
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Authors
K. Scott, J. Saul, I. Crooks, O.M. Camacho, D. Dillon, C. Meredith,