| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5861984 | Toxicology in Vitro | 2013 | 9 Pages |
Abstract
⺠Aggregating brain cell cultures (AGGR) were used to detect alerts for neurotoxicity. ⺠The toxicity of compounds in AGGR was compared with that reported in 3T3 cell line. ⺠The frequency of alerts increased with the toxic potency of the chemicals in AGGR. ⺠AGGR were found to be suitable for the detection of organ-specific toxicity.
Keywords
LD50multicenter evaluation of in vitro cytotoxicityMEICIC20Concentration–response analysisAggregating brain cell cultures3T3Hsp32EU CLPNF-HLOECADMEMBPGFAPThree-dimensionalNRUIn vitro testingneutral red uptakeabsorption, distribution, metabolism and excretionDIVday in vitroAcute oral toxicityNeurotoxicityGlial fibrillary acidic proteinMyelin basic proteinlowest observed effect concentration
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Authors
Marie-Gabrielle Zurich, Sven Stanzel, Annette Kopp-Schneider, Pilar Prieto, Paul Honegger,