| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862118 | Toxicology in Vitro | 2012 | 10 Pages |
Abstract
⺠High concentration of ACR or high-efficiency NO donors are toxic for hMPC. ⺠High-efficiency NO donors increase RNS/ROS levels in cell cytoplasm leading to cell necrosis. ⺠High concentration of ACR induces apoptosis through the RNS/ROS independent mechanisms. ⺠ACR has no modulatory effect on the expression of bone sialoprotein and osteopontin. ⺠NO donors, but not ACR, act through guanylate cyclase-dependent differentiation pathway.
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Authors
Åukasz Szewczyk, Justyna UlaÅska, Marta Dubiel, Anna Maria Osyczka, Grzegorz Tylko,