| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862156 | Toxicology in Vitro | 2012 | 8 Pages |
Abstract
⺠Exposure of DHEA to bovine liver slices results in increased androgenic activity. ⺠Formation of various (androgenic) metabolites of DHEA could be confirmed by UPLC-TOFMS analysis. ⺠DHEA gene expression profiles are comparable to those of the potent androgen 17Ã-testosterone. ⺠Bovine liver slices allow the assessment of various effect-based endpoints for prohormone exposure.
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Authors
Jeroen C.W. Rijk, Toine F.H. Bovee, Ad A.C.M. Peijnenburg, Maria J. Groot, Ivonne M.C.M. Rietjens, Michel W.F. Nielen,