Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862160 | Toxicology in Vitro | 2012 | 8 Pages |
Abstract
⺠A novel process reduced the levels of proteins and polyphenols in tobacco. ⺠Levels of some tobacco smoke constituents were reduced, including aromatic amines. ⺠Aromatic amines might contribute to the bacterial mutagenicity of tobacco smoke particulate matter. ⺠The novel process reduced the bacterial mutagenicity of tobacco smoke particulate matter. ⺠The novel process did not affect in vitro mammalian genotoxicity of tobacco smoke particulate matter.
Keywords
Nicotine-free dry particulate matterMLABATRPMIOECDNIHIC50TFTMnBnOrganisation of Economic Cooperation and DevelopmentDMEMPost-mitochondrial supernatantNFDPMDMSONRUSALnot testedSalmonella mutagenicity assayIn vitro micronucleus teststandard deviationUnited StatesISOanalysis of varianceANOVABritish American Tobaccothymidine kinaseneutral red uptakeDulbecco’s Minimal Essential MediumStandard error of measurementIn vitrodimethyl sulphoxideparticulate matterCytotoxicityGenotoxicityTobacco smokeMutation frequencyNIH, National Institutes of HealthSEMCooperation Centre for Scientific Research Relative to TobaccoICHRoswell Park Memorial Institute mediuminternational conference on harmonization of technical requirements for registration of pharmaceuticals for human useCORESTA
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
R. Combes, K. Scott, D. Dillon, C. Meredith, K. McAdam, C. Proctor,