Article ID Journal Published Year Pages File Type
5862185 Toxicology in Vitro 2013 11 Pages PDF
Abstract
► This study examined cytotoxic mechanisms of zearalenone metabolites, α-ZOL and β-ZOL. ► β-ZOL induced cell death mainly by apoptosis rather than necrosis. ► β-ZOL caused mitochondrial-mediated and caspase-independent cell death. ► β-ZOL led to the activation of p53 and c-Jun N-terminal kinase-mediated signaling. ► Oxidative stress and AIF relocation was also involved in β-ZOL-mediated cytotoxicity.
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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