| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862198 | Toxicology in Vitro | 2013 | 7 Pages |
Abstract
⺠Lead (Pb), at >25 μM, increases MHC-II surface expression resulting in immune dysregulation. ⺠Data on exposure to environmentally relevant Pb levels in macrophages are lacking. ⺠Environmental Pb exposure inhibited metabolic activity and increased MHC-II surface expression. ⺠Environmental Pb exposure induced autophagy, and increased MHC-II trafficking, a novel finding. ⺠Pb exposure is a novel mechanism in which macrophages may enhance self-antigen expression.
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Authors
R.P. Kerr, T.M. Krunkosky, D.J. Hurley, B.S. Cummings, S.D. Holladay, R.M. Jr.,