| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862223 | Toxicology in Vitro | 2013 | 7 Pages |
Abstract
⺠Animal models for skin sensitization needs to be replaced with in vitro assays. ⺠Dendritic cells are paramount for initiation of sensitization. ⺠GARD is a novel assay utilizing MUTZ-3 as an in vitro dendritic cell model. ⺠Readout is based on predictive biomarker signatures.
Keywords
TLRTNFLLNAMUTZ-3ACDAHRLMWNrf2DMSOLocal lymph node assayinterferonIFNQSARAssayToll-like receptorSkin sensitizationACD, Allergic contact dermatitisIn vitroDimethyl sulfoxideQuantitative structure-activity relationshipAlternative methodsDendritic cellLangerhans cellNuclear factor-erythroid 2-related factor 2tumor necrosis factorSupport vector machineSVMcell-basedlow molecular weightaryl hydrocarbon receptor
Related Topics
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Health, Toxicology and Mutagenesis
Authors
Henrik Johansson, Ann-Sofie Albrekt, Carl A.K. Borrebaeck, Malin Lindstedt,