Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862252 | Toxicology in Vitro | 2014 | 7 Pages |
Abstract
This work tests the hypothesis that the marine algal toxin yessotoxin (YTX) can trigger ribotoxic stress response in L6 and BC3H1 myoblast cells. YTX exposure at a concentration of 100Â nM displays the characteristics of a ribotoxic stress response in such cells. The exposure leads to activation of the p38 mitogen-activated protein kinase, the stress-activated protein kinase c-jun, and the double-stranded RNA-activated protein kinase (PKR). YTX treatment also causes ribosomal RNA cleavage and inhibits protein synthesis. These observations support the idea that YTX can act as a ribotoxin.
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Authors
Mónica Suárez Korsnes, Susan Skogtvedt Røed, Michael A. Tranulis, Arild Espenes, Berit Christophersen,