| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862323 | Toxicology in Vitro | 2012 | 7 Pages |
Abstract
⺠We examine the effects of quercetin on HO-1 expression in rat hepatocytes. ⺠Quercetin up-regulated HO-1 expression in hepatocytes. ⺠HO-1 induction was involved in the hepatoprotective effect of quercetin. ⺠ERK/Nrf2 signaling pathway participated in HO-1 induction by quercetin in hepatocytes.
Keywords
PI3KMDAnuclear factor erythroid 2 related factor 2CYP 2E1Heme oxygenase-1ERKHO-1GSHNrf2CATPBSJnk3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromidec-Jun N-terminal kinaseMAPKMTTROSALDASTOxidative damageEthanolQuealcoholic liver diseaseaspartate transaminaseSODSuperoxide dismutasecytochrome P450 2E1antioxidant response elementPhosphatidylinositol 3-kinaselactate dehydrogenaseLDHmalondialdehydePhosphate-buffered salineAREmitogen-activated protein kinaseCatalaseQuercetinextracellular signal-regulated kinaseGlutathioneReactive oxygen species
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Authors
Shuang Liu, Wei Hou, Ping Yao, Na Li, Biyun Zhang, Liping Hao, Andreas K. Nüssler, Liegang Liu,