Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862355 | Toxicology in Vitro | 2013 | 9 Pages |
Abstract
However, TCC was shown to interfere with the regulon of the aryl hydrocarbon receptor (AhR) as TCC showed a costimulatory effect on transcription of CYP1A1 and CYP1B1, effectively lowering the transcriptional threshold for both genes in the presence of estrogens. It thus seems, that while the induction of the respective luciferase reporter assays by TCC is an unspecific false positive signal caused by luciferase stabilisation, TCC has the potential to interfere with the regulatory crosstalk of the estrogen receptor (ER) and the AhR regulon.
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Authors
Patrick Tarnow, Tewes Tralau, Danele Hunecke, Andreas Luch,