| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862386 | Toxicology in Vitro | 2013 | 6 Pages |
Abstract
⺠Metabolic capability is needed in in vitro systems for improving in vivo relevance. ⺠Bioreactors produce metabolites for target exposure. ⺠Preservation by appropriate culture conditions enhance metabolic competence. ⺠Incorporation by genomic techniques restore metabolism in otherwise deficient cells. ⺠Stem cell-derived hepatocytes will guarantee unlimited supply of competent cells.
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Authors
Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Khaled Abass, Markku Pasanen, Hannu Raunio, Kirsi Vähäkangas,