| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862467 | Toxicology in Vitro | 2013 | 13 Pages |
Abstract
⺠Mitragynine was evaluated for its effects on CYP1A2, CYP2D6 and CYP3A4 activities. ⺠It has no significant effects on CYP2D6. ⺠It induces mRNA and enzymatic activity of CYP1A2 significantly. ⺠It induces CYP3A4 weakly at the transcriptional level. ⺠It inhibits CYP3A4 weakly by interacting with the enzyme.
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Authors
Ee Lin Lim, Tiong Chai Seah, Xue Fen Koe, Habibah Abdul Wahab, Mohd Ilham Adenan, Mohd Fadzly Amar Jamil, Mohamed Isa Abdul Majid, Mei Lan Tan,