| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862496 | Toxicology in Vitro | 2013 | 10 Pages |
Abstract
⺠A 384-well dual parameter assay for assessing drug-induced mitochondrial dysfunction in cells was validated. ⺠The assay measures cellular oxygen consumption and extracellular acidification in both suspension and adherent cells. ⺠Two hundred drugs were tested in this assay and in two previously established mitochondrial toxicity assays. ⺠The dual parameter assay identified more compounds that cause mitochondrial impairment than the other two assays. ⺠Novel information was obtained on drugs not previously reported to cause mitochondrial impairment.
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Authors
James Hynes, Sashi Nadanaciva, Rachel Swiss, Conn Carey, Sinead Kirwan, Yvonne Will,