Cosmetics Europe multi-laboratory pre-validation of the EpiOcularâ¢ reconstituted human tissue test method for the prediction of eye irritation

Article ID	Journal	Published Year	Pages	File Type
5862504	Toxicology in Vitro	2013	8 Pages	PDF

Abstract

âº Successful transfer of the EpiOcularâ¢ EIT protocol from method developer to other laboratories. âº Very good within and between laboratory reproducibility demonstrated for liquid and solid test articles. âº Results support progression of the test method into a full prospective ECVAM validation study.

Keywords

OECD ECVAM BLV HCE EIT ICCVAM RHT Isolated Chicken Eye test ECVAM Scientific Advisory Committee ESAC EU CLP SCC BCOP UN GHS Eye irritation test European Union standard deviation Human corneal epithelium Irritation analysis of variance ANOVA In vitro REACH United Nations Globally Harmonized System of Classification and Labelling of Chemicals Organisation for Economic Co-operation and Development Prediction model European Centre for the Validation of Alternative Methods Eye optical density Interagency Coordinating Committee on the Validation of Alternative Methods Ice

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Cosmetics Europe multi-laboratory pre-validation of the EpiOcularâ¢ reconstituted human tissue test method for the prediction of eye irritation

Authors

U. Pfannenbecker, S. Bessou-Touya, C. Faller, J. Harbell, T. Jacob, H. Raabe, M. Tailhardat, N. Alépée, A. De Smedt, B. De Wever, P. Jones, Y. Kaluzhny, B. Le Varlet, P. McNamee, M. Marrec-Fairley, F. Van Goethem,