| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862572 | Toxicology in Vitro | 2011 | 9 Pages |
Abstract
⺠An increase ROS level with a decrease in glutathione level suggests nano-SiO2-induced free radical generation and glutathione depletion. ⺠A decrease in cell viability associated with ROS level suggests the role of oxidative stress on nano-SiO2 induced cell death. ⺠An increase in thiobarbituric-acid reactive species level suggests nano-SiO2-induced membrane damage caused by lipid peroxidation. ⺠An increase in a cell shrinkage and a nuclear condensation suggesting nano-SiO2-induced cell apoptosis. ⺠Nano-SiO2 exposure diminishes the ability of neurite extension in response to NGF in treated PC12 cells.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Fen Wang, Changping Jiao, Jianwen Liu, Huihui Yuan, Minbo Lan, Feng Gao,