| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862583 | Toxicology in Vitro | 2011 | 8 Pages |
Abstract
⺠We investigate ATZ induced transcriptional changes in steroidogenesis markers in cultured rat interstitial Leydig cells. ⺠ATZ exposure (25 and 50 μg/ml) for 48 h onwards was found to be cytotoxic. ⺠MTT assay shows better sensitivity than NRU assay. ⺠ATZ significantly alters the levels of mRNA expression of steroidogenic markers in dose dependent manner. ⺠Study suggests the applicability of cultured Leydig cells as screening tool to assess the anti-steroidogenic activity.
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Authors
S.O. Abarikwu, E.O. Farombi, M.P. Kashyap, A.B. Pant,