Dermal penetration of propylene glycols: Measured absorption across human abdominal skin in vitro and comparison with a QSAR model

► Dermal penetration of propylene glycols measured in vitro is compared with a QSAR model. ► The measured Jss and Kp for MPG were 97.6 μg/cm2/h and 9.48 × 10−5 cm/h, respectively. ► The measured Jss and Kp for DPG were 39.3 μg/cm2/h and 3.85 × 10−5 cm/h, respectively. ► The model slightly over-predicted Jss and Kp by between 2.6- and 5.1-fold.