Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells

Article ID	Journal	Published Year	Pages	File Type
5862650	Toxicology in Vitro	2011	11 Pages	PDF

Abstract

âº The anticarcinogenic effects of three flavanols on Caco-2 and SW480 colon cancer cells were studied. âº Exposure of SW480 cells to epicatechin gallate led to apoptosis. âº Procyanidin B2 activated cell proliferation and survival/proliferation pathways in SW480 cells. âº Flavanols showed different cytotoxicity depending on their chemical structure and cell differentiation degree.

Keywords

GPX 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD98059 PB2 LY294002 tert-butylhydroperoxide epicatechin Epigallocatechin-3-gallate DCFH OPT ERK EGCG GST GSH DTT FBS 2′,7′-dichlorofluorescin diacetate 5-bromo-2′-deoxyuridine ROS t-BOOH Akt/PKB ECG epicatechin gallate BrdU Apoptosis dithiothreitol Colorectal cancer Colon cancer fetal bovine serum lactate dehydrogenase LDH protein kinase B Procyanidin B2 CRC extracellular regulated kinase Glutathione glutathione-S-transferase glutathione reductase glutathione peroxidase Reactive oxygen species