Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862656 | Toxicology in Vitro | 2011 | 7 Pages |
Abstract
⺠OA induced cytotoxicity and apoptosis in MG63 cells at IC50 of 75 nM. ⺠A functional PKR pathway is required to induce apoptosis in response to OA treatment. ⺠Blockade of NF-κB by PDTC resulted in down-regulation of apoptosis. ⺠The caspase-3 and caspase-8 inhibitors blocked apoptosis in MG63 cells.
Keywords
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Ling Chen,