Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862790 | Toxicology in Vitro | 2013 | 8 Pages |
Abstract
The hepatocyte culture conditions established in this study proved to be valuable for investigation of the induction of equine CYPs. In further studies, other equine drugs can be evaluated for CYP induction with this in vitro system.
Keywords
7-ethoxy-4-trifluoromethylcoumarinHFCHTKEFC7-benzyloxy-4-trifluoromethylcoumarinHBSSBFCEGTAWEMFBSDMEM7-hydroxy-4-trifluoromethylcoumarinCYPsDMSODulbecco’s modified Eagle mediumcytochrome P450 enzymesethylene glycol tetraacetic acidHorseInductiondimethyl-sulphoxideRifampicinfetal bovine serumCytochrome P450Hanks’ balanced salt solutionHepatocyteHistidine-tryptophan-ketoglutarate
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Authors
A. Stefanski, M. Mevissen, A.-M. Möller, K. Kuehni-Boghenbor, A. Schmitz,