Article ID Journal Published Year Pages File Type
5862809 Toxicology in Vitro 2013 11 Pages PDF
Abstract
► Vero-E6 (kidney) and HepG2 (hepatoma) cell lines were exposed to a wide range of microcystin-LR concentrations. ► In both cell lines, lysosomal destabilization precedes mitochondrial impairment. ► In both cell lines, autophagy is triggered at non-cytotoxic MCLR concentrations as a survival mechanism. ► The endoplasmic reticulum is involved in MCLR toxicity in HepG2 cells but not in Vero-E6 cells.
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Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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Involvement of endoplasmic reticulum and autophagy in microcystin-LR toxicity in Vero-E6 and HepG2 cell lines
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