| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862811 | Toxicology in Vitro | 2013 | 8 Pages |
Abstract
⺠Tumor-derived hepatocytes are more prone to the cytotoxic effects of xanthohumol. ⺠Xanthohumol promotes Nrf2 activation followed by the induction of phase II enzymes. ⺠Induction of HO-1 and GST may explain the antioxidative potential of xanthohumol. ⺠Xanthohumol elevates the expression of NQO1 and promotes p53 accumulation. ⺠The induction of cytoprotective enzymes may prevent liver damage in normal tissue.
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Authors
Violetta Krajka-Kuźniak, JarosÅaw Paluszczak, Wanda Baer-Dubowska,