| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862815 | Toxicology in Vitro | 2013 | 12 Pages |
Abstract
⺠This is an original global gene expression analysis on saporin-treated cancer cells. ⺠The transcriptional response is consistent with protein synthesis inhibition. ⺠The antioxidant N-acetylcysteine partially blocks apoptosis induced by the toxin. ⺠b-SO6 is a potent ribosome-inactivating protein that induces oxidative stress. ⺠An antibody-avidin fusion protein targeting the TfR1 effectively delivers b-SO6.
Keywords
BFU-ELFCCHXNHLTfR1KLF6TXNIPBMMCGadd45bNIHburst forming unit-erythroidCFU-GMCFU-EBHLHB2colony forming unit-erythroidDNSLTC-ICBCATransferrinTBPqPCRNACkiloDaltonGAPDHkDaHRPN-acetylcysteineROSImmunotoxinbicinchoninic acidOxidative stressBone marrow mononuclear cellscycloheximidesaporinNIH, National Institutes of HealthMultiple myelomaquantitative polymerase chain reactionMolecular weightRIPHorseradish peroxidaseTATA-box binding proteinRibosome-inactivating proteinThioredoxin interacting proteinglyceraldehyde 3-phosphate dehydrogenaseReactive oxygen speciestransferrin receptor 1
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Authors
Tracy R. Daniels-Wells, Gustavo Helguera, José A. RodrÃguez, Lai Sum Leoh, Michael A. Erb, Graciel Diamante, David Casero, Matteo Pellegrini, Otoniel MartÃnez-Maza, Manuel L. Penichet,