| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862824 | Toxicology in Vitro | 2013 | 10 Pages |
Abstract
⺠This study examined the effects of SB-273005 on murine EC and VSMC monocultures and cocultures. ⺠SB-273005-induced aortic VSMC toxicity is not mediated or enhanced through EC/VSMC interactions. ⺠A direct effect of SB-273005 on mouse VSMC was observed. ⺠SB-273005 induced an increase in cytotoxicity and caspase-3/7 and -9 activity in VSMC monocultures. ⺠SB-273005-induced toxicity in VSMC cultures is mediated through the intrinsic apoptotic pathway.
Keywords
VSMCβ-APNRFUαVβ5EcGSαvβ3RLUECMFCSHBSSDAPIDMEMFBSDPBSVascular injuryallylaminediamidino-2-phenylindolefetal bovine serumfetal calf serumVascular smooth muscle cellsEndothelial cellsDulbecco’s phosphate buffered salineExtracellular matrixHank’s balanced salt solutionDulbecco’s modified eagle’s mediumendothelial cell growth supplementRelative Fluorescence Unitsrelative light units
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Authors
Deidre A. Dalmas Wilk, Marshall S. Scicchitano, Diane Morel,