Article ID Journal Published Year Pages File Type
5862839 Toxicology in Vitro 2013 10 Pages PDF
Abstract
► Fragrant chemicals lyral/lilial decreased viability of HaCat cells. ► lyral/lilial-decreased ATP level and increased: ROS level and LDH release in HaCat cells. ► Lyral/lilial inhibited liver sub-mitochondrial particles complexes I and II activities of respiratory chain. ► Antioxidants restored control ROS level; lipoic acid protected the viability of lilial and lyral treated Hacat cells. ► Lyral and lilila are mitochondriotoxin with direct and indirect effect on HaCat cells.
Keywords
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
Fragrance chemicals lyral and lilial decrease viability of HaCat cells' by increasing free radical production and lowering intracellular ATP level: Protection by antioxidants
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