| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862847 | Toxicology in Vitro | 2013 | 7 Pages |
Abstract
⺠Chemical irritants increase intracellular calcium. ⺠Intracellular calcium increase may be a biomarker of skin irritation. ⺠The irritant heptylamine induces ATP release by keratinocytes. ⺠ATP acts as an autocrine stimulus on keratinocyte. ⺠Analyse of the keratinocyte contribution to chemical stimuli detection.
Keywords
NHKPPADSPLCIL8HBSSPGE2NRREGTASLSDMEMF/F0TNFαinterleukine 8EGFneutral red releaseDMSO[Ca2+]iAdenosine TriphosphateATPtumor necrosis factor αstandard error of the meanIrritant contact dermatitisDimethyl sulfoxidesodium lauryl sulfateCalcium signalingepidermal growth factorintracellular calcium concentrationphospholipase CHanks’ balanced salt solutionDulbecco’s modified eagle’s mediumSEMSkinKeratinocytenormal human keratinocytes
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Authors
Matthieu Raoux, Nathalie Azorin, Cécile Colomban, Stéphanie Rivoire, Thierry Merrot, Patrick Delmas, Marcel Crest,