Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862918 | Toxicology in Vitro | 2011 | 13 Pages |
Abstract
⺠Acute oral toxicity data (LD50) were used to derive rat and mouse baseline toxicity models. ⺠The non-linear QSARs were fitted by saturated monohydric alcohols and monoketones. ⺠Predictivities of the models were evaluated with an external hydrocarbon test set. ⺠The models allow for the formation of mechanistic categories for excess toxic chemicals. ⺠Species sensitivity was assessed by the relationship between LD50 values for rat and mouse.
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Authors
Yana K. Koleva, Mark T.D. Cronin, Judith C. Madden, Johannes A.H. Schwöbel,