| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5862932 | Toxicology in Vitro | 2011 | 7 Pages |
Abstract
⺠Cytotoxicity assays showed that TQ was more potent towards SiHa cells and less cytoxic towards 3T3-L1 and Vero cells as compared to cisplatin. ⺠TQ caused morphological changes in SiHa cells at higher concentration of TQ (30 μg/mL). ⺠Cell cycle analysis, Annexin V-FITC/PI and AO/PI tests indicated that TQ was cytotoxic towards SiHa cells by involving apoptosis. ⺠Cytotoxicity of TQ in SiHa cells involved a significant elevation of the level of the p53 activity and the Bax to Bcl-2 ratio.
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Authors
Wei Keat Ng, Latifah Saiful Yazan, Maznah Ismail,