In vitro skin penetration of fragrances: Trapping the evaporated material can enhance the dermal absorption of volatile chemicals

Article ID	Journal	Published Year	Pages	File Type
5862933	Toxicology in Vitro	2011	7 Pages	PDF

Abstract

âº The article describes an in vitro study of the evaporation and skin absorption of fragrances. âº Evaporation rates measured on skin and on synthetic substrates differ significantly. âº Trapping chambers can hinder the evaporation of volatiles and enhance their dermal absorption. âº These effects distort the risk assessment of fragrances and lead to unrealistic margins of safety.

Keywords

PBS C10 In vitro skin penetration MOS FRM PBST EDT PDMS PTFE GC/FID GC/MS Risk assessment Evaporation Systemic absorption Margin of safety Decanol Franz diffusion cell Coefficient of Variation Fragrance phosphate buffer saline Stratum corneum polytetrafluoroethylene Polydimethylsiloxane gas chromatography with flame ionization detection gas chromatography coupled with mass spectrometry