Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5862989 | Toxicology in Vitro | 2012 | 8 Pages |
Abstract
⺠T-2 Toxin enhanced catabolic gene expression in hypertrophic chondrocytes. ⺠HIF-2α was a crucial mediator in T-2 toxin treatment. ⺠T-2 Toxin induced the degradation of IκB-α and the production of ROS. ⺠We confirmed that ROS-NF-κB-HIF-2α pathway participated in the process.
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Authors
Juan Tian, Jidong Yan, Wei Wang, Nannan Zhong, Lifang Tian, Jian Sun, Zixin Min, Jie Ma, Shemin Lu,