Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency

Article ID	Journal	Published Year	Pages	File Type
5863008	Toxicology in Vitro	2012	11 Pages	PDF

Abstract

âº The predictive capacity of h-CLAT for potency categorization was examined. âº Correspondence between LLNA EC3 and several indicators in h-CLAT was compared. âº The minimum induction threshold (MIT) of h-CLAT was correlated to LLNA EC3. âº The MIT was expected to discriminate strong sensitizer and weak sensitizer.

Keywords

MFI Human Maximization Test HRIPT RFI COLIPA NOEL GHS LLNA h-CLAT ECETOC DPRA OECD hMT eC3 Risk assessment mit Human Repeated Insult Patch Test Murine local lymph node assay registration, evaluation, authorization and restriction of chemicals alternative Skin sensitization REACH Organization for Economic Cooperation and Development Dendritic cell globally harmonized system of classification and labeling of chemicals geometric mean fluorescence intensity relative fluorescence intensity European Centre for Ecotoxicology and Toxicology of Chemicals Keratinocyte