| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5863082 | Toxicology in Vitro | 2012 | 8 Pages |
Abstract
⺠We use human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs). ⺠Responsiveness of hES-CMCs to hERG blockers differed widely. ⺠hES-CMCs are selected according to responsiveness to cisapride, a hERG blocker. ⺠Selected hES-CMCc are validated by responsiveness to several reference compounds. ⺠We establish robust QT evaluation system by pharmacological selection of hES-CMCs.
Keywords
FBSE-4031CisaprideNEAAAPD90APDHERGFPDDMEMQT intervalDMSOISInon-essential amino acidsbpmDimethyl sulfoxidefetal bovine serumbeats per minuteinter-spike intervalDulbecco’s modified eagle’s mediumAction potential durationaction potential duration at 90% repolarizationfield potential durationhuman ether-à-go-go-related gene
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Authors
Kazuto Yamazaki, Taro Hihara, Tomohiko Taniguchi, Naohiro Kohmura, Takashi Yoshinaga, Masashi Ito, Kohei Sawada,