| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5877746 | The Journal of Pain | 2013 | 10 Pages |
Abstract
Our novel findings indicated that simvastatin attenuated formalin-induced nociceptive responses by inhibiting microglial RhoA and p38 mitogen-activated protein kinase activation. Inactivation of RhoA-p38 signaling pathway may be a pharmacologic target for treating microglia-directed central nervous system inflammation and chronic pain conditions.
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Authors
Xin-Yi Chen, Kai Li, Alan R. Light, Kai-Yuan Fu,