Pregabalin Suppresses Nociceptive Behavior and Central Sensitization in a Rat Trigeminal Neuropathic Pain Model

Trigeminal nerve injury in rats produced facial mechanical hypersensitivity and trigeminal central sensitization of medullary dorsal horn neurons that were markedly attenuated by systemically administered pregabalin, suggesting its potential clinical utility for orofacial neuropathic pain.