| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5880225 | The Journal of Pain | 2014 | 35 Pages |
Abstract
Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation. When treatment is delayed, minocycline, but not riluzole, reverses pre-established hypersensitivity. Thus, these drugs may provide a new translational treatment option for chronic avulsion injury pain.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Daniel J. Chew, Thomas Carlstedt, Peter J. Shortland,