| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5880889 | The Journal of Pain | 2013 | 12 Pages |
Abstract
The development of morphine tolerance represents a significant impediment to its use in the management of chronic pain. We report that morphine tolerance is accompanied by increased glial cell activation within the vlPAG, and that the presence of a persistent pain state prevented vlPAG glial activation and attenuated morphine tolerance.
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Authors
Lori N. Eidson, Anne Z. Murphy,