Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5883086 | Clinical Lymphoma Myeloma and Leukemia | 2015 | 6 Pages |
Abstract
We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells. These data indicated that STAT inhibition by dasatinib might be therapeutic in JAK/STAT pathway-associated malignancies after confirmation with clinical studies.
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Authors
Ceyda Tunakan Dalgıç, Burçin Tezcanlı Kaymaz, Melda Cömert Ãzkan, AyÅegül Dalmızrak, Fahri Åahin, Güray Saydam,