| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5884476 | Journal of Clinical Anesthesia | 2016 | 6 Pages |
â¢We investigated effect of mean sugammadex doses and compared to neostigmine
Study objectiveSugammadex is an alternative drug to traditional decurarization by cholinesterase inhibitors. It has been examined the effect of sugammadex on steroid hormones in this study.DesignRandomized clinical trial.SettingThe study was conducted in a University Teaching Hospital from January 2013 to May 2014.PatientsFifty male patients between 18 and 45Â years of age with an American Society of Anesthesiology (ASA) class I or II undergoing elective lower extremity surgery were included in this study.InterventionsPatients were categorized into two groups (neostigmin group, Group N; and sugammadex group, Group S). In addition to standard monitorization, train-of-four (TOF) was also used to monitorize the level of neuromuscular blockade. Standard induction and maintenance of anesthesia were performed. At the termination of surgery, neuromuscular blockade was antagonized using 0.05Â mg/kg of neostigmine and 0.01Â mg/kg of atropin when spontaneous recovery of neuromuscular blockade occurred with the reappearance of T2 in Group N and using 4Â mg/kg sugammadex in Group S.MeasurementsThe primary outcome in this study was to determine serum aldosterone, cortisol, progesterone, and free testosterone levels. Three blood samples were obtained in each patient just before and 15Â minutes and 4Â hours after antagonism,Main resultsNo significant differences were found in demographic characteristics between the groups. While there were no differences in serum progesterone levels, patients in neostigmin group had significantly higher cortisol levels at 15Â minutes as compared to baseline. Also, patients in sugammadex group had significantly higher serum aldosterone and testosterone levels 15Â minutes after antagonism as compared to those in the neostigmine group.ConclusionsOur findings suggest that sugammadex is not associated with adverse effects on steroid hormones progesterone and cortisol, while it may lead to a temporary increase in aldosterone and testosterone.
