Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5887479 | Seminars in Arthritis and Rheumatism | 2016 | 7 Pages |
Abstract
ObjectiveTo assess the relationship between active inflammation and development of chronic lesions in the spine and sacroiliac (SI)-joints on MRI in early axial spondyloarthritis (SpA) during treatment with etanercept.MethodsHere, we analyzed the 41 patients of the ESTHER trial, who were treated with etanercept over 3 continuous years and of whom MRIs were available for baseline, year 2, and year 3. MRIs were scored for active inflammation (STIR sequences) and chronic changes (T1 sequence) such as fatty lesions, erosions, and ankylosis in the SIÂ joints and spinal vertebral units (VUs).ResultsThe mean fatty lesion scores increased between baseline and year 2 both in the spine (1.13 at baseline vs. 1.40 at year 2, p = 0.0254) and in the SI joints (4.76 at baseline vs. 5.46 at year 2, p = 0.27), but we found no further increase of the fatty lesion score between years 2 and 3. New fatty lesions at years 2 and 3 developed nearly exclusively in SI joint quadrants and VUs in which active MRI inflammation was present at baseline. Fatty lesions disappeared only in 3 SI joint quadrants and in none of VUs at years 2 and 3. Erosion and ankylosis scores remained unchanged.ConclusionOur data indicate a relationship between the presence of active MRI inflammation and the new development of fatty lesions. Furthermore, there was no increase of fatty lesions during continuous treatment of axial SpA patients with etanercept after successful suppression of active inflammation. Whether this is predictive of stopping radiographic progression needs to be further investigated.Significance and Innovations
- This is the first study prospectively following inflammatory lesions, including fatty lesions on MRI of spine and sacroiliac joints of patients with early axial SpA treated over 3 years of continuous treatment with a TNF-inhibitor.
- No further increase of fatty lesions between year 2 and year 3 was found in early axial SpA patients treated continuously with etanercept.
- Our data indicate a strong relationship between the presence of active MRI inflammation and the new development of fatty lesions.
- Whether this is predictive of stopping radiographic progression needs to be further investigated.
- This is the first study prospectively following inflammatory lesions, including fatty lesions on MRI of spine and sacroiliac joints of patients with early axial SpA treated over 3 years of continuous treatment with a TNF-inhibitor.
- No further increase of fatty lesions between year 2 and year 3 was found in early axial SpA patients treated continuously with etanercept.
- Our data indicate a strong relationship between the presence of active MRI inflammation and the new development of fatty lesions.
- Whether this is predictive of stopping radiographic progression needs to be further investigated.
Keywords
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Authors
In-Ho Song, Kay-Geert Hermann, Hildrun Haibel, Christian E. Althoff, Denis Poddubnyy, Joachim Listing, Anja WeiÃ, Bruce Freundlich, Ekkehard Lange, Martin Rudwaleit, Joachim Sieper,