Colchicine-Update on mechanisms of action and therapeutic uses

Article ID	Journal	Published Year	Pages	File Type
5887598	Seminars in Arthritis and Rheumatism	2015	58 Pages	PDF

Abstract

Further understanding of the mechanisms of action underlying the therapeutic efficacy of colchicine will lead to its potential use in a variety of conditions.

Keywords

IC50 P-gp MDR1 P2X7 FMF CYP3A4 ABCB1 MLCK TLR NALP3 SRF Bcl-2 RhoA ASC CCF SNPs CPPD NSAIDS NF-κB TNFα TGF-β1 Rho-associated, coiled-coil containing protein kinase Calcium pyrophosphate dihydrate crystals VGEF MYD88 P-glycoprotein 1 MSU 50% inhibitory concentration Ca2+ras homolog gene family, member A ROS Adenosine Triphosphate ATP Therapeutic use inflammation interleukin Familial Mediterranean fever Transforming growth factor beta-1 tumor necrosis factor α Non-steroidal anti-inflammatory drugs myosin light chain kinase cytochrome P450 3A4 Pharmacokinetics Vascular endothelial growth factor nuclear factor κB serum response factor B-cell lymphoma 2 Mechanism of action Nitric oxide myeloid differentiation primary response gene 88 C-reactive protein CRP Single nucleotide polymorphisms Monosodium urate crystals caspase Calcium colchicines Reactive oxygen species Toll-like receptors Rock

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Colchicine-Update on mechanisms of action and therapeutic uses

Authors

Ying Ying MD, Laura Li MD, Virginia B. MD, PhD,