Cell therapy for the treatment of tendinopathy - A systematic review on the pre-clinical and clinical evidence

The current evidence was inadequate to make a conclusion whether cell therapy was safe and effective. Further study with adequate sample size and follow-up time, appropriate controls and optimal blinding is required. Confirmation of finding, using different tendinopathy animal models, by systematic investigation of the effects of cell sources, dosages and regimens on the outcomes, and by the inclusion of tendon pain assessment in both animals and human, is recommended. Research on the mechanisms of how cell worked in tendon repair is essential.